Abstract:
A modified silk fibroin scaffold with mimic reconstructed extracellular matrix of decellularized pulp/collagen/fibronectin was proposed for bone tissueengineering in alveolar bone resorption. Silk fibroin scaffolds were fabricated by freeze-drying before modification by coating in a decellularizedpulp/collagen/fibronectin solution. The extracellular matrix reconstruction of the decellularized pulp/collagen/fibronectin and the morphology and biofunctionalities of the modified scaffolds were evaluated. The results showed that decellularized pulp/collagen/fibronectin organized into a dense dendrite structure and adhered in the scaffold in a fibrillar network. The modified scaffold showed predominant biofunctionalities and promise for bone tissueengineering in alveolar bone resorption. (C) 2015 Elsevier B.V. All rights reserved. Source: Materials Letters Author: Sangkert S, Kamonmattayakul S, Chai WL, Meesane J. Status: A paid open access available at ScienceDirect
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